Clinical & Scientific Program 2025

Mitochondrial Medicine 2025 offers an international platform for experts in mitochondrial research and provides programs designed to inspire emerging scientists. Attendees will gain insights into the latest advancements in mitochondrial medicine, including industry innovations, potential treatments, therapies, and pioneering research. This event uniquely enables the scientific community to engage directly with affected patients, fostering a deeper understanding of the lived experience of mitochondrial disease and accelerating progress toward a cure.

NEW – A limited number of travel scholarships will be available this year for young researchers, early career investigators, and clinicians new to the field of mitochondrial medicine.

Please note – agenda subject to change based on speaker availability.

Wednesday, June 18

Morning – Platform Session 1 – NAMDC Sessions – Michio Hirano, Chair

8:00a-8:30a	Welcome and Opening Remarks *UMDF Staff and Chairs* *Patient Story –* NAMDC Patient – MELAS, PDCD, or POLG
8:30a-9:00a	North American Mitochondrial Disease Consortium Impact Michio Hirano, MD, Columbia University Irving Medical Center
9:00a-10:00a	Patient Engagement in NAMDC to Advance the Diagnostic Journey and Disease Understanding · Emanuele Barca, MD, PhD, Columbia University Irving Medical Center · Valentina Emmanuele, MD, PhD, Columbia University Irving Medical Center · JLP Seamus Thompson, PhD, Columbia University Irving Medical Center · Johan Van Hove, MD, PhD, Children’s Hospital of Colorado
*10:00a-10:30a*	*Break*
10:30a-11:30a	Clinical Trial Readiness, Clinical Studies, and Clinical Trials · Zuela Zolkipli Cunningham, MD, Children’s Hospital of Philadelphia · Jirair Bedoyan, MD, PhD, University of Pittsburgh · Fernando Scaglia, MD, Baylor College of Medicine
11:30a-12:00p	Career Enhancement Program – Pilot Projects · Richard Haas, MD, University of California San Diego · Austin Larson, MD, Children’s Hospital of Colorado · Zuela Zolkipli Cunningham, MD, Children’s Hospital of Philadelphia · Others TBD
12:00p-12:15p	Abstract Short Talk Presentation – Non CME
12:15p-12:30p	Abstract Short Talk Presentation – Non CME

Afternoon – Platform Session 2 – Inflammation and Metabolic Diseases

2:00p-2:30p	In Vivo Assessment of Diabetes in Primary Mitochondrial *Shana McCormack, MD, MTR, Children’s Hospital of Philadelphia*
2:30p-3:00p	Mitochondrial Regulation of Thermogenic Fat Activation *Jun Wu, PhD, University of Michigan, Life Sciences Institute*
3:00p-3:30p	Disruption of Mitochondrial Dynamics by Obesity-Dependent Increase in RaIA Activity *Alan Saltiel, MD, University of California San Diego*
*3:30p-4:00p*	*Break*
4:00p-4:30p	The Role of Mitophagy in Diabetes *Scott A. Soleimanpour, MD, University of Michigan*
4:30p-5:00p	2 Abstract Short Talk Presentations – Non CME
5:00p-5:30p	2 Abstract Short Talk Presentations – Non CME
5:30p-7:30p	*Break and Poster Sessions* *Even Numbers Stay at Posters – NON CME*

Thursday, June 19

Morning – Platform Session 3 – Mitochondria on the Move

NOTE: A special Mitochondrial Medicine Society Clinician Track will run concurrently from 8am to 12:30pm – more details coming soon!

8:00a-8:30a	Mito Transfer and Transplantation Elicits Angiogenesis by Inducing Mitophagy *Juan Melero-Martin, PhD, Boston Children’s / Harvard*
8:30a-9:00a	Release of Cell-free Mitochondria into the Blood *Alain Thierry, PhD, INSERM/Montpelier University, France*
9:00a-9:30a	Inter-organ Transfer of Mitochondria from Adipocytes to the Heart *Clair Crewe, PhD, Washington University St. Louis*
9:30a-10:00a	2 Abstract Short Talk Presentations – Non CME
*10:00a-10:30a*	*Break*
10:30a-11:00a	Mitochondrial Metabolism in the Nervous System *Speaker TBD*
11:00a-11:30a	2 Abstract Short Talk Presentations – Non CME
11:30a-12:00p	2 Abstract Short Talk Presentations – Non CME
12:00p-12:30p	2 Abstract Short Talk Presentations – Non CME
*12:30p-2:00p*	*Lunch*

Afternoon – Platform Session 4 – Mechanisms of Clearing Damaged Mito (mitophagy, autophagy)

2:00p-2:30p	Mitochondrial Quality Control *Åsa Gustafsson, PhD,* *University of California San Diego*
2:30p-3:00p	Mitochondrial Dynamics and Mitochondrial Quality Control David Chan, MD, PhD, California Institute of Technology
3:00p-3:30p	Topic Title: TBD Jonathan Friedman, MD, UT Southwestern
*3:30p-4:00p*	*Break*
4:00p-4:30p	Mitophagy in Health and Disease *Martin Graef, PhD, Cornell University*
4:30p-5:00p	2 Abstract Short Talk Presentations – Non CME
5:00p-5:30p	2 Abstract Short Talk Presentations – Non CME
5:30-6:00p	2 Abstract Short Talk Presentations – Non CME
6:00p-8:00p	Poster Sessions – Odd Numbers Stay at Posters – Reception Note: Poster Sessions are NON CME

Friday, June 20

Morning – Platform Session 5 – Combined Sessions/Clinical Trial Updates – NON CME

8:00a-10:00a	Combined Sessions for All Attendees (SciMed, Patients/Families, Industry) – NON CME Welcome: UMDF and the State of the Mitochondrial Medicine Community and IMPACT Join us for the accelerator Big Pitch Presentations!
*10:00a-10:30a*	*Break*
10:30a-12:30p	*Clinical Trial Updates – NON CME:Presenters TBD***
*12:30p-2:00p*	*Lunch*

Afternoon – Platform Session 6 – Multi-omics

2:00p-2:30p	Systems Biochemistry Approaches to Defining Mitochondrial Protein Function *David Pagliarini, PhD, Washington University of St. Louis*
2:30p-3:00p	Massively Parallel Single-cell Mitochondrial DNA Genotyping *Vijay G. Sankaran, MD, PhD, Boston Children’s &* *Harvard Medical School*
3:00p-3:30p	Multi-omics Discovery Platform for Metabolic Gene Function *Eric Gamazon, PhD, MS, Vanderbilt University Medical Center*
*3:30p-4:00p*	*Break*
4:00p-4:30p	Integrative Omics Analyses to Improve Diagnostic Rates of Mendelian Disorders *Holger Prokisch, PhD, Helmholtz Zentrum München*
5:00p-5:30p	Abstract Cash Award Presentations *Philip Yeske, PhD, UMDF Science & Alliance Officer*
5:30p-9:30p	UMDF Evening of Energy Reception and Banquet Celebration for ALL Attendees

Saturday, June 21

Morning – Platform Session 7 – Mito Med TK2d MasterClass for “Up and Coming” Clinicians and Early Career Investigators

NEW platform session with two tracks for “up and coming” clinicians and early career investigators. There will be a focus on Primary Mitochondrial Myopathy and TK2d for the clinician track.

Clinical Chairs: Michio Hirano, MD; Fernando Scaglia, MD; and Austin Larson, MD

Early Career Chairs: Jon Brestoff, PhD; Natalie Niemi, PhD; and Brett Kaufman, PhD

Agenda details to come!